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Cancer Services

Gastrointestinal Cancer

Please see below all current gastrointestinal cancer clinical trials of the Central Coast Cancer Centre.

Medical Oncology clinical trials

Name: OXTOX

Can oxaliplatin neurotoxicity be reduced with ibudilast in people with metastatic colorectal cancer – a phase II randomised study

Principal Investigator: Dr Matthew Wong
Study Coordinator: Bronwyn Raymond
Status: Recruiting
Condition: Colorectal Cancer

Name: INTEGRATE II

A Randomised Phase III Double-Blind Placebo-Controlled Study of regorafenib in Refractory Advanced Gastro-Oesophageal Cancer (AGOC)

Principal Investigator: Dr Matthew Wong
Study Coordinator: Bronwyn Raymond
Status: Recruiting
Condition: Gastrointestinal Cancer
External page link INTEGRATE II

Name: Protocol 8951-CL-5201

A phase 2, open-label, randomized study to assess the antitumor activity and safety of Zolbetuximab (IMAB362) in combination with Nab-Paclitaxel and Gemcitabine (Nab-P + GEM) as first line treatment in subjects with Claudin 18.2 (CLDN 18.2) positive, metastatic pancreatic adenocarcinoma.

Principal Investigator: Dr Matthew Wong
Study Coordinator: Michelle Dixon
Status: Recruiting
Condition: Pancreatic Cancer
External page link Protocol 8951-CL-5201

Name: MK 6482

An Open-label, multicentre, phase II study to evaluate the efficacy and safety of pembrolizumab plus lenvatinib in combination with belzutifan in multiple solid tumours.

Principal Investigator: Dr Matthew Wong
Study Coordinator: Cassandra Rubio
Status: Recruiting
Condition: Hepatocellular, Endometrial, Oesophageal Cancer
External page link MK 6482

Name: STAR-221

A Randomised, open-label, Multicentre Phase 3 Trial of Domvanalimab, Zimberelimab, and Chemotherapy in Participants with Previously Untreated Locally Advanced Unresectable or Metastatic gastric Gastroesophageal Junction, and Esophageal Adenocarcinoma

Principal Investigator: Dr Craig Kukard
Study Coordinator: Abraham Mathews
Status: Recruiting
Condition: Gastro-Oesophageal Cancer
External page link STAR-221

Radiation Oncology clinical trials

Name: LARK

The LARK Clinical Trial Liver Ablative Radiotherapy utilising Kilovoltage Intrafraction Monitoring (KIM).

Principal Investigator: Dr Simon Tang
Study Coordinator: Richard Clayton
Status: Recruiting
Condition: Liver Cancer
External page link LARK

More information

For more information about medical oncology clinical trials, please contact the Nurse Unit Manager on 02 4320 9890 or see:

Internal page Research and Clinical Trials

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